RESUMO
Congenital Zika infection has been linked with a characteristic phenotype including neurologic sequelae. However, West syndrome has not been previously well described as a consequence. We aim to show this association through a retrospective descriptive study performed in Ecuador. Among 147 infants with congenital Zika infection, 7.5% suffered from West syndrome. Vigabatrin seems to be effective to control the spasms.
Assuntos
Espasmos Infantis/virologia , Infecção por Zika virus/congênito , Infecção por Zika virus/complicações , Zika virus/patogenicidade , Anticonvulsivantes/uso terapêutico , Equador/epidemiologia , Feminino , Humanos , Lactente , Masculino , Microcefalia/virologia , Fenótipo , Gravidez , Complicações Infecciosas na Gravidez/virologia , Estudos Retrospectivos , Espasmos Infantis/tratamento farmacológico , Espasmos Infantis/epidemiologia , Vigabatrina/uso terapêuticoRESUMO
BACKGROUND: Few congenital Zika syndrome (CZS) cases have been notified in Ecuador and, to our knowledge, there are no significant published studies dealing with their clinical evolution. We present a detailed clinical characterization of 21 children with congenital Zika virus (ZIKV) infection born in Ecuador who were followed up until September 2019. METHODS: We did a retrospective longitudinal study of children attended by the infectious disease specialists of Francisco Icaza Bustamante Children's Hospital (Guayaquil) due to congenital ZIKV infection suspicion. The inclusion criteria consisted of laboratory confirmed diagnosis of congenital ZIKV infection. RESULTS: Sixteen of these 21 cases of congenital ZIKV infection showed clinical, neuroimaging and laboratory findings strongly suggestive of CZS and 5 children showed laboratory findings compatible with congenital ZIKV infection without congenital manifestations associated to CZS. All children with CZS showed neurodevelopmental delay, spasticity and hyperreflexia during follow-up, whereas the majority of them (14/15) experienced recurrent epileptic seizures and dysphagia (12/13). Two CZS cases died during follow-up. Visual evoked potential and hearing screening with acoustically evoked auditory brainstem response were abnormal in 50% and 37.5% of CZS cases, respectively. Congenital ZIKV infection without findings consistent with CZS at birth was not clinically relevant at 23 months of age in the five cases of our cohort. CONCLUSIONS: Severe neurodevelopmental delay, severe microcephaly, epileptic seizures and dysphagia were present at 2 years of age in most CZS cases of our cohort.
Assuntos
Microcefalia , Complicações Infecciosas na Gravidez , Infecção por Zika virus , Zika virus , Criança , Equador/epidemiologia , Potenciais Evocados Visuais , Feminino , Humanos , Lactente , Estudos Longitudinais , Microcefalia/epidemiologia , Gravidez , Estudos Retrospectivos , Infecção por Zika virus/complicações , Infecção por Zika virus/diagnóstico , Infecção por Zika virus/epidemiologiaRESUMO
Se describe el caso de una paciente de quince años de edad, que presentó cefalea, disminución de la agudeza visual, de tres años de evolución con carácter progresivo. Se realizó una Topografía de Cerebro computada que mostró un gran Meningioma, Hidrocefalia y edema vasogénico. Realizada la exéresis total del tumor, la hidrocefalia se resolvió espontáneamente y el edema con tratamiento farmacológico. Se revisa la bibliografía.
A case of a fifteen year-old patient that who has been experiencing migraine for three years, a decrease of the visual sharpness of progressive character. A PET scan was done we could visualize that the patient had a great on Meningioma., hydrocephalus, and vasogenic edema. Removing the tumor the hydrocephalus was resolved and the edema received pharmacological treatment.